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Attribute
Biological Foundation Models

ESM-3

EvolutionaryScale
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CategoryBiological Foundation Models
CompanyEvolutionaryScale
PriceFree open weights (1.4B) / Paid enterprise API
StatusStatus not confirmed
AvailabilityGlobally available via AWS Bedrock and EvolutionaryScale API
Last checked20/09/2026
FeaturesSimultaneous multimodal generation across sequence, coordinates, and secondary structure, Promptable with structural motifs, active site geometries, or sequence fragments, Demonstrated de novo generation of fluorescent proteins with 500M years of divergent evolution, Available in 1.4B open weights, 7B, and 98B parameter frontier configurations
Entry typeAI Model
Access modeOpen weights & Cloud API
AI roleMultimodal Generative AI
Input dataNot recorded
Output dataNot recorded
Licence conditionsEvolutionaryScale Open Model License (1.4B) / Commercial Cloud API
Commercial eligibilityCommercial API & enterprise licenses available; non-commercial for open weights
Compute requirements1x A100 GPU (1.4B open model) to multi-node H100 clusters (98B model)
ValidationNot recorded
TypeGenerative protein language & structure model
Intended useNot recorded
CompatibilityNot recorded
ManufacturerEvolutionaryScale
Biological applicationDe novo protein generation, motif scaffolding, and functional sequence design
Research workflowStructure & function generation from biological prompts
Evidence levelPeer-reviewed research and experimental wet-lab validation (Science 2024)
Integration evidencehttps://www.evolutionaryscale.ai/blog/esm-3-release
Laboratory handoffOutput FASTA sequences can be sent directly to gene synthesis vendors (Twist, IDT)