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Biological AI Models · Protein Design

RFdiffusion

By RosettaCommons / Baker Lab →

Diffusion-based protein backbone design

Research software for protein backbone generation and design tasks. This entry covers the original RFdiffusion repository; it does not conflate RFdiffusion2 or RFdiffusion3.

Diffusion-based protein backbone designDocumented research workflow
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Overview

Research software for protein backbone generation and design tasks. This entry covers the original RFdiffusion repository; it does not conflate RFdiffusion2 or RFdiffusion3.

Information checked against an official source; not a hands-on test. Source · Last reviewed: 14/09/2026, 18:31:56

Key Features

  • Diffusion-based protein backbone design
  • Documented research workflow
Interactive 3D Structure

RFdiffusion Predicted Complex

Streams real 3D atomic coordinates from RCSB Protein Data Bank
⇄ Drag to rotate · Scroll to zoom
pLDDT / B-Factor:
>90 Very high 70-90 Confident 50-70 Low <50 Very low

Academic Context & Research Evidence

Biological & Workflow Fit

Compute & Hardware
Version and workload dependent; not independently benchmarked
Licensing & Academic Use
Check repository licence and checkpoint terms
Documented Evidence
Project documentation; no local benchmark

Cite this Tool

Use this citation format when referencing RFdiffusion in scientific publications and benchmark papers.

@software{rfdiffusion_2026,
  title = {{RFdiffusion}},
  author = {{RosettaCommons / Baker Lab}},
  year = {2026},
  url = {https://github.com/RosettaCommons/RFdiffusion},
  note = {Indexed on aibioatlas - AI for Biology and Drug Discovery}
}

Peer-Reviewed Literature & Preprints

Live scientific citations streamed from Europe PMC and PubMed for RFdiffusion.

⏳ Fetching real-time literature from Europe PMC & PubMed...

Technical / Product Information

Missing values mean the catalog has no recorded information. They do not mean a feature is absent.

Entry typeResearch software / model
Access modePublic code
AI roleMachine-learning software
Input dataDesign constraints and optional structural motifs
Output dataDesigned protein backbones
Licence conditionsCheck repository licence and checkpoint terms
Commercial eligibilityConfirm exact code, weights and data terms
Compute requirementsVersion and workload dependent; not independently benchmarked
ValidationEvaluate on representative held-out data
TypeNot recorded
Intended useNot recorded
CompatibilityNot recorded
Evidence levelProject documentation; no local benchmark
AvailabilityPublic code
Price / accessSee access and licence terms

Research fit & compatibility

No software–hardware integration has been verified for this entry yet. Explore documented research workflows.

Gallery & resources

No licensed product photograph recorded for RFdiffusion yet. Visit the official resource below for manufacturer imagery.

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FAQ

Where is this product available?

Public code

How is pricing handled?

Prices reflect the source at its last check. Confirm current pricing and regional availability on the official site.

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Peer Reviews & Community Ratings

Feedback from researchers and computational biologists evaluating RFdiffusion.

5.0
★★★★★Based on 0 researcher evaluations
Biological Accuracy
4.8/5
Ease of Installation
4.3/5
Documentation & Code
4.6/5